Global Health Institute

EBOVAC3

EBOVAC PROJECT

EBOVAC3 project: Open-label, Randomized, Clinical Trial to Evaluate the Immunogenicity and Safety of a Prophylactic Vaccination of Health Care Providers by Administration of a Heterologous Vaccine Regimen Against Ebola in the Democratic Republic of the Congo

This open-label, single-centre, randomised phase 2 vaccine trial was performed in Boende, Democratic Republic of the Congo, with health care providers and frontliners as trial participants, as they are more at risk of contracting and spreading the Ebola virus disease. The primary and a secondary outcome of this trial was to evaluate the immunogenicity and safety of the Ad26.ZEBOV, MVA-BN-Filo vaccine regimen, administered at a 56-day interval. Overall, vaccine regimen and booster dose were well-tolerated and led to a durable immune response in study participants, supporting the use of the regimen and booster dose for prophylactic vaccination of at risk populations. 

Geographical overview of partnerships/ongoing research:



Learn more on EBOVAC3 in the links below: 

EBOVAC3 - General project information (click to open expansion pannel to read more)

Summary

The EBOVAC3 project aims to assess, through clinical trials in children and adults in Africa, the safety and effectiveness of an Ebola vaccine regimen. As such it will help to improve the world’s preparedness to deal with an Ebola outbreak. The project focuses on the ‘prime-boost’ Ebola vaccine regimen (Ad26.ZEBOV and MVA-BN-Filo) prime-boost’ Ebola vaccine regimen, in which patients are first given a dose to prime the immune system, and then a boost dose which is intended to enhance the immune response over time. Building on work carried out under the EBOVAC1 and 2 projects, EBOVAC3 will run clinical trials in children in Sierra Leone, Guinea and the Democratic Republic of Congo. It will also follow up people who participated in earlier clinical trials in Sierra Leone, to assess the safety and efficacy of the vaccine in the longer term. Finally, the project aims to characterize the outbreak preparedness of Sierra Leone, Guinea and the Democratic Republic of Congo.

Funding

The EBOVAC3 project has received funding from the IMI2 Joint Undertaking. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme, European Federation of Pharmaceutical Industries and Associations (EFPIA) and the Coalition for Epidemic Preparedness Innovations (CEPI). For this trial, the Contract Research Organisation and part of the FANG ELISA analyses are funded by the CEPI. All other trial activities are funded by the IMI2 Joint Undertaking grant. All vaccines and neutralizing antibody level analyses against Ad26 at the first visit are provided by Janssen Vaccines & Prevention B.V. .​

Partner(s)

  • University of Kinshasa, Janssen Vaccines & Prevention B.V., ACE Research and DFNet Research
  • External partners: The London School of Hygiene and Tropical Medicine (LSHTM), the Institut National de la Santé et de la Recherche Médicale (INSERM), and the College of Medicine and Allied Health Sciences (COMAHS)

Period

01/06/2018 - 30/09/2024

more information on and

Articles on EBOVAC3

    • , , , , Milolo Solange, Laurent Nicolas, , Adroabadrio Douglas, Baelo Pascal, Ngoy Steve, Ansobi Papy, Nebesse Casimir, Peeters Martine, Ayouba Ahidjo, Champagne Maeliss, Bouillin Julie, , , , , ...
    • PLoS pathogens - ISSN 1553-7366 - 21:11(2025), e1013628
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:219573]

    • , , , , Larivière Ynke, , , Longomo Emmanuel Esanga, Milolo Solange, Matangila Jr Junior, Maketa Vivi, Mitashi Patrick, , Muhindo-Mavoko Hypolite, 
    • JMIR Formative Research - ISSN 2561-326X - 9(2025), e54921
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:214627]

    • , Larivière Ynke, , , , Maketa Vivi, Muhindo-Mavoko Hypolite, , Mitashi Patrick, , , 
    • Vaccine / International Society for Vaccines - ISSN 1873-2518 - 55(2025), 127000
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:212914]

    • , Larivière Ynke, Milolo Solange, , , Mitashi Patrick, , Ravinetto Raffaella, , Muhindo-Mavoko Hypolite, Maketa Vivi, 
    • PLoS ONE - ISSN 1932-6203 - 20:6(2025), p. 1-18
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:214978]
  • ...
    • Larivière Ynke, , , Milolo Solange, Meta Rachel, Kimbulu Primo, Robinson Cynthia, Katwere Michael, McLean Chelsea, , Matangila Junior, Maketa Vivi, Mitashi Patrick, , , Muhindo-Mavoko Hypolite
    • The lancet infectious diseases - ISSN 1474-4457 - 24:7(2024), p. 746-759
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:204672]

    • , Larivière Ynke, , , Kimbulu Primo, Milolo Solange, Danoff Engbu, Tchuma Yves, Maketa Vivi, Mitashi Patrick, Ravinetto Raffaella, , , Muhindo-Mavoko Hypolite
    • BMJ Global Health - ISSN 2059-7908 - 9:6(2024), e015259
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:206260]

    • , , , Larivière Ynke, , , , Matangila Junior, Maketa Vivi, Esanga Emmanuel, Milolo Solange, Mitashi Patrick, , Muhindo-Mavoko Hypolite, e
    • The American journal of tropical medicine and hygiene - ISSN 1476-1645 - 111:3(2024), p. 578-588
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:206894]
    • , Larivière Ynke, , , , Milolo Solange, Meta Rachel, Matangila Junior, Maketa Vivi, Mitashi Patrick, , Muhindo-Mavoko Hypolite, 
    • Vaccine / International Society for Vaccines - ISSN 1873-2518 - 42:3(2024), p. 481-488
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:204647]
    • , , Larivière Ynke, Milolo Solange, Danoff Engbu, Bakonga Lazarre, Esanga Emmanuel, , Maketa Vivi, Matangila Junior, Mitashi Patrick, , , Ravinetto Raffaella, Muhindo-Mavoko Hypolite
    • Research Ethics - ISSN 2047-6094 - 20:1(2024), p. 79-95
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:198711]

    • Larivière Ynke, , , , Milolo Solange, Meta Rachel, Kimbulu Primo, Robinson Cynthia, Katwere Michael, Mclean Chelsea, , Matangila Junior, Maketa Vivi, Mitashi Patrick, Muhindo-Mavoko Hypolite, , 
    • The journal of infectious diseases - ISSN 1537-6613 - Cary, Oxford univ press inc, 229:4(2024), p. 1068-1076
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:199228]
    • , , , , Milolo Solange, Laurent Nicolas, Fourchault Léa, Adroabadrio Douglas, Baelo Pascal, Ngoy Steve, Ansobi Papy, Nebesse Casimir, Peeters Martine, Ayouba Ahidjo, Champagne Maeliss, Bouillin Julie, , , , , ...
    • bioRxiv, 2024, 24 p. 
    • Full text (DOI publisher):  
    • Full text (open access):  [c:irua:217018]

    • Larivière Ynke, , , , , Milolo Solange, Meta Rachel, Kimbulu Primo, Esanga Emmanuel, Matangila Junior, , , Maketa Vivi, Muhindo-Mavoko Hypolite, Mitashi Patrick
    • Vaccine / International Society for Vaccines - ISSN 1873-2518 - 41:51(2023), p. 7587-7597 
    • Full text (DOI publisher):  
    • Full text (open access):  [c:irua:201420]
    • , , Larivière Ynke, , , 
    • Vaccine / International Society for Vaccines - ISSN 1873-2518 - 41:25(2023), p. 3701-3709
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:196461]

    • Crevecoeur Jonas, , Neyens Thomas, Larivière Ynke, Verhasselt Bruno, Masson Hanna, 
    • Vaccine / International Society for Vaccines - ISSN 1873-2518 - 40:43(2022), p. 6218-6224
    • Full text (DOI publisher):  
    • Full text (open access):  [c:irua:196760]

    • , Larivière Ynke, , , Milolo Solange, Meta Rachel, Esanga Emmanuel, , , , , Maketa Vivi, Matangila Junior, Mitashi Patrick, Muhindo-Mavoko Hypolite
    • Vaccine / International Society for Vaccines - ISSN 1873-2518 - 40:25(2022), p. 3470-3480
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:189016]

    • , Larivière Ynke, Zola Tresor Matuvanga, Maketa Vivi, Matangila Junior, Mitashi Patrick, , , , Muhindo Hypolite Mavoko, Ravinetto Raffaella, , 
    • BMJ Global Health - ISSN 2059-7908 - 6:6(2021), e005726
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:179716]

    • , Larivière Ynke, , , , , 
    • Clinical infectious diseases - ISSN 1537-6591 - 73:6(2021), p. E1305-E1313
    • Full text (DOI publisher):  [c:irua:184643]

    • Larivière Ynke, Zola Tresor, , Maketa Vivi, Matangila Junior, Mitashi Patrick, , Muhindo-Mavoko Hypolite, , 
    • BMJ open - ISSN 2044-6055 - 11:9(2021), e046835
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:182460]

    • Inac Yasemin, Larivière Ynke, Hoque Muhammad, 
    • African health sciences - ISSN 1680-6905 - 21:1(2021), p. 123-131
    • Full text (DOI publisher): 
    • Full text (open access):  [c:irua:180572]

    • Matuvanga Tresor Zola, Johnson Ginger, Larivière Ynke, Longomo Emmanuel Esanga, Matangila Junior, Maketa Vivi, Lapika Bruno, Mitashi Patrick, Mc Kenna Paula, , , , Mavoko Hypolite Muhindo
    • Journal of medical internet research - ISSN 1438-8871 - 23:8(2021), e28573
    • Full text (DOI publisher): 
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