Abstract
The project, Microbiota Intervention Strategies Limiting Selection and Transmission of Antibiotic Resistance burden in the One Health domain (MISTAR, https://www.jpiamr.eu/projects/mistar/) aims to bring perspectives on novel interventions to reduce the emergence of antibiotic resistance that can readily be integrated into existing organisational structures that are also applicable in low-and-middle income countries, and innovative technologies, which need further investment.
MISTAR aims to implement and quantify the effect of novel intervention strategies based on the preservation of the "healthy microbiota" to eradicate and control the spread of antimicrobial resistance (AMR). ¶¶Òõ¶ÌÊÓƵ laboratories are studying resistomes in a global context, using a One Health approach, and aims to (1) Predict and prevent antibiotic-induced microbial dysbiosis in the gut and post-antibiotic resistome response, (2) Develop microbiota-based rapid point of care diagnostic pipelines for AMR detection, (3) Determine the efficacy of CRISPR-Cas target intervention on resistome across reservoirs.
The project is funded by Joint Programming Initiative in Antimicrobial Resistance (JPIAMR, 13th call, 2021) and FWO.
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