Koen Augustyns full professor

Koen Augustyns

PhD Students

  1. 26/09/2000          : Design, synthesis and biological evaluation of opioid-related prolyl peptides and pseudopeptides
  2. 10/11/2000          : Design, synthesis and evaluation of dipeptidyl peptidase IV (DPP IV) inhibitors
  3. 25/06/2002          : Glutathionylspermidine synthetase as a target in the design of new trypanocidal compounds
  4. 30/09/2002          Gunther Bal: Dipeptidyl peptidase IV and prolyl oligopeptidase: design, synthesis and evaluation of substrates and inhibitors
  5. 29/03/2004         Pieter Van der Veken: Design, synthesis and biochemical evaluation of peptidomimetic inhibitors of dipeptidyl-peptidase IV and dipeptidyl-peptidase II
  6. 31/03/2004          : Design and synthesis of potent and selective inhibitors for dipeptidyl peptidase II
  7. 23/04/2004          : Design, synthesis and evaluation of glutathionylspermidine synthetase inhibitors as potential trypanocidal drugs
  8. 24/10/2005          : Synthesis and biochemical evaluation of matrix metalloproteinase and urokinase plasminogen activator inhibitors targeting angiogenesis and metastasis
  9. 30/10/2006          : Development of nucleoside hydrolase inhibitors as potential antiparasitic agents
  10. 02/10/2007          Anna Soroka: Design and synthesis of potent and selective inhibitors for dipeptidyl peptidase II and dipeptidyl peptidase 8
  11. 26/06/2008          : Synthesis of aminoalkylamino-substituted neocryptolepine analogues: valorization of the cryptolepine alkaloids as antimalarials
  12. 24/11/2009          : Design, Synthesis and Biochemical Evaluation of New Cysteine Protease Inhibitors as Potential Antiparasitic Agents
  13. 21/05/2010          : Targeting the Trypanosomatidae: Inhibitor Development for Nucleoside Hydrolases and Metacaspases
  14. 05/09/2011          : Structure-activity relationship studies on inhibitors of dipeptidyl peptidases 8 and 9: is selectivity an attainable goal?
  15. 13/06/2013          : Synthesis and biochemical evaluation of inhibitors and activity-based probes for uPA and related serine proteases
  16. 09/12/2013          : Cysteine protease inhibitors for protozoan infections: metacaspases as promising new targets
  17. 27/03/2014          Koen Jansen: Potent and selective inhibitors of fibroblast activation protein (FAP)
  18. 03/07/2015           Synthesis and structure-activity exploration of novel compound series with potential towards the treatment of systemic fungal infections
  19. 09/07/2015          : Heteroannelated pyrrolidines and prolines as inhibitors of dipeptidyl peptidases and related enzymes
  20. 10/05/2016          Rafaela Gladysz: Fragment-based approaches to inhibitors of urokinase plasminogen activator (uPA)
  21. 16/12/2016          : Discovery of novel Atg4B inhibitors with a benzotropolone core structure and therapeutic evaluation in a HT29 colon carcinoma mouse xenograft model
  22. 02/02/2017          : Structural investigation of two novel classes of quinoloxyacetamide- and hydantoin-based antimycobacterials guided by phenotypic screening and targeted approaches
  23. 04/09/2017          : Implementation of carboxylate isosteres to improve inflammatory caspase inhibitors
  24. 06/11/2017          : Identification, lead optimization and validation of necroptosis and ferroptosis inhibitors
  25. 10/11/2017          : Optimization of biorthogonal pretargeting for immuno-PET imaging in transgenic mouse models of Alzheimer’s disease
  26. 18/09/2018          : Discovering of necroptosis and ferroptosis inhibitors with potential applications in pathologies associated with regulated necrosis
  27. 09/10/2019          : Design, synthesis and characterization of alpha-amino diaryl phosphonates as serine protease inhibitors with applications in antimicrobial drug discovery
  28. 19/11/2019          : Formulation development of poorly water-soluble compounds using solubility enhancement methods
  29. 30/03/2020          : Development of novel chemical tools for bioorthogonal pretargeted PET imaging
  30. 04/10/2021          : Strecker-type reactions and MSAS as tools for protease inhibitor discovery
  31. 17/11/2021          : Profiling and structural investigation of dihydrotriazine-based DHFR inhibitors and hydantoin-derived DprE1 inhibitors in search of novel antimycobacterials
  32. 27/06/2023          : Design, synthesis and evaluation of novel activity-based probes and inhibitors for trypsin-like serine proteases - Focus on Dry eye disease (DED) and Irritable bowel syndrome (IBS)
  33. 20/09/2023           Identification of novel ferroptosis and necroptosis inhibitors – Optimizing the therapeutic potential by improving the pharmacokinetic properties
  34. 2024                     : Phenotypic and target based approach to antitubercular drug discovery: investigation of thienopyrimidine and hydantoin scaffolds as new hits against Mycobacterium tuberculosis
  35. 2024                      Development of new TCO probes for pretargeted PET imaging