Research team
Expertise
Our research focuses on the role of platelets, coagulation, and inflammation in ischemic stroke. From a translational perspective, we integrate experimental stroke models with clinical data and patient samples to dissect the interplay between thrombosis, vascular dysfunction, and neuroinflammation. We investigate how these mechanisms impact cerebral blood flow, neuronal injury, and functional recovery. Ultimately, we aim to develop innovative therapeutic strategies that enhance post-stroke recovery. Our expertise lies at the intersection of hematology, vascular biology, and neuroinflammation, with a particular focus on platelet activation, immunothrombosis, and microvascular reperfusion failure.
The role of immunothrombosis in ischemic stroke
Abstract
Ischemic stroke occurs when a cerebral artery is obstructed by a blood clot, triggering rapid neuronal injury and long-term disability. More than 94 million people worldwide currently live with the consequences of ischemic stroke, making it a leading cause of morbidity and a major societal burden. Platelets are key drivers of both stroke onset and the subsequent progression of brain damage. However, currently used antiplatelet therapies provide only partial protection and cannot be applied indiscriminately, as platelets also play essential roles in maintaining cerebrovascular integrity and preventing intracranial bleeding. A more refined understanding of distinct platelet pathways is therefore urgently needed to guide the development of safer and more effective stroke treatments. In this project, we combine an advanced preclinical mouse model with in-depth experimental analyses. We use a modified mouse model that enables more detailed investigation of interactions between platelets and immune cells. This humanized model provides a more biologically relevant context to study immunothrombosis during stroke. Additional molecular and cellular studies will further support these findings. This integrated approach will help clarify the role of platelets and immune cells and may potentially lead to new therapeutic targets.Researcher(s)
- Promoter: Denorme Frederik
Research team(s)
Project type(s)
- Research Project