DRP1 depletion protects NK cells from hypoxia-induced dysfunction

CD70-directed CAR natural killer cells as novel off-the-shelf cell therapy in colorectal and pancreatic cancer targeting tumor cells and their microenvironment

Source
Antwerpen, Universiteit Antwerpen, Faculteit Geneeskunde en Gezondheidswetenschappen, 2025,222 p.

Self-sufficient primary natural killer cells engineered to express T cell receptors and interleukin-15 exhibit improved effector function and persistence

Source
Frontiers in immunology - ISSN 1664-3224-15 (2024) p.
Author(s)
    Els P. van Hees, Laura T. Morton, Dennis F. G. Remst, Anne K. Wouters, Astrid Van den Eynde, J. H. Frederik Falkenburg, Mirjam H. M. Heemskerk

IL-15-secreting CAR natural killer cells directed toward the pan-cancer target CD70 eliminate both cancer cells and cancer-associated fibroblasts