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​â¶Ä‹â¶Ä‹â¶Ä‹â¶Ä‹Meeting objectives: 

• HPV prevention and control in People Living With HIV 
  • Discuss and review the HPV vaccine schedule for People Living With HIV 
  • Discuss HPV screening of People Living With HIV 
    
  • Discuss and review the management of women with HIV who are HPV positives
    
• Benefits and Challenges of Immunobridging trials 
  • Discuss availability and use of different HPV immunoassays
  • Discuss challenges and prospects of immunobridging trials for evaluating current and future HPV vaccines
• DNA Methylation as a triage tool for cervical cancer screening
  
  • Provide an overview of the use of DNA methylation in the oncology field
  • Provide an overview of different DNA methylation assays and methods
  • Discuss the use of DNA methylation as a novel biomarker for triage of human papillomavirus (HPV) positive women at screening

Introduction video

Thursday, 2 June 2022

SESSION 1 : WELCOME AND INTRODUCTION

• Welcome & Introduction
  Alex Vorsters & Dur-e-Nayab Waheed  (, )
  

SESSION 2: HPV PREVENTION AND CONTROL IN PEOPLE LIVING WITH HIV

​​Chairs: Maribel Almonte & Silvia de Sanjose

• Global HIV Epidemiology and the intersection with HPV and cervical cancer burden
  Gary Clifford (, )
  
  
• ​Performance and effectiveness of screeningtriage strategies for cervical precancer among women living with HIV
  Helen Kelly (, )
  
  
• Questions and Discussion ()
  
  

• Management of women with HIV who are HPV positive
  Hennie Botha (, )
  
  

• Improving HPV & precancer treatment among WLWH in LMICs: The Low Hanging Fruit
  Chemtai Mungo (, )
  
  
• Questions and Discussion ()
  
  

• HPV vaccination in people living with HIV
  Sinead Delany-Moretlwe (, )​
  
  
• Questions and Discussion ()
  
  

• Keynote lecture: Prevention of anal cancer in males and females living with HIV
  Joel Palefsky 
  

SESSION 3: BENEFITS AND CHALLENGES OF IMMUNOBRIDGING

Chairs: Partha Basu & Deborah Watson-Jones

• Immunogenicity of HPV prophylactic vaccines: Serology assays and their use in HPV vaccine evaluation and development. Importance of international units for reporting immune response
  Carina Eklund (, )
  
  
• Neutralizing and cross-neutralizing antibody levels to human papillomavirus following vaccination
  Filipe Colaço Mariz (, )
  
  
• Questions and Discussion ()
  
  
• Current status of using urine samples to monitor HPV vaccination status
   Alex Vorsters & Laura Téblick  (, )​
  
  
• Monitoring of HPV vaccination programs
  Iacopo Baussano 
  
  
• Questions and Discussion ()
  
  
• Update on April 2022 SAGE advice on HPV schedule optimization and the permissive single dose recommendation in younger women
  Paul Bloem (, )
  
  
• One dose modelling study in India
  Iacopo Baussano
  
  
• Questions and Discussion ()

SESSION 3A: PANEL DISCUSSION
One dose

Chairs: Margaret Stanley & Peter Dull

• Single-dose HPV vaccination efficacy among adolescent girls and young women in Kenya (the KEN SHE ¶¶Òõ¶ÌÊÓƵ): study protocol for a randomized controlled trial
  Nelly Mugo (, )
  
  
• The DoRIS trial results to M36-immunogenicity of 1 dose of gardasil9®and cervarix® in Tanzanian girls aged 9-14Y and M24 immunobridging results
  Deborah Watson-Jones (, )​
   
• Costa Rica HPV Vaccine Trials
  Aimee Kreimer (, )​
  
  
• Multicentric cohort study to compare efficacy of a single dose of 4-HPV vaccine compared to two &three doses in 10-18 yr old females in India
  Partha Basu (, )​
   
• Hope ¶¶Òõ¶ÌÊÓƵ: Population impact of a single HPV vaccine dose on HPV 16/18 prevalence among South African adolescent girls
  Sinead Delany-Moretlwe (, )
   
• Panel discussion - Speakers and participants ()
  Nelly Mugo, Deborah Watson-Jones, Aimee Kreimer, Sinead Delany-Moretlwe, Paul Bloem, Gary Clifford, Partha Basu  

Topics:

• One dose
• One dose use in women living with HIV
  
• Implementation of one dose in LMICs

Friday, 3 June 2022

SESSION 4: DNA METHYLATION AS A TRIAGE TOOL FOR CERVICAL CANCER SCREENING
Chairs: Mario Poljak & Kate Cuschieri

• Welcome
  Alex Vorsters
  
  
• Methylation in predicting progression of untreated high-grade cervical intraepithelial neoplasia 
  Karolina Louvanto (, )​
   
• Overview of different DNA methylation assays used in HPV screening
  Mariam El-Zein (, )
   
• Methylation patterns of host cell DNA and the heterogeneous nature of cervical pre-cancer
  Daniëlle Heideman ()
   
• Methylation of viral DNA and combined viral and host DNA methylation
  Jack Cuzick
   
• DNA methylation testing on clinician-collected cervical and self-collected vaginal samples for identification of cervical lesions in high-risk HPV positive women
  Johannes Berkhof (, )
  
  
• Human Papillomavirus DNA Methylation as a Biomarker for Cervical Precancer: Consistency across 12 Genotypes and Potential Impact on Management of HPV-Positive Women
  Megan Clarke (, )
   
• Questions and Discussions. ()
  
  
• Could DNA methylation be used as a primary cervical screening method?
  Belinda Nedjai (, )
   
• Evaluation of  cervical screening strategies using methylation markers in WLHIV
  Chris Meijer (, )
   
• The standing of self-collected urine samples for DNA methylation in cervical screening
  Severien Van Keer  (, )
  
  
• Questions and Discussions ()

SESSION 5: BREAKOUT SESSION
Chairs: Alex Vorsters & Marc Arbyn

1. Breakout Group 1: HPV Prevention and Control in HIV Positives – challenges and lessons learnt
   Chairs: Marc Steben & Sharon Hanley
   
   
2. Breakout Group 2: Benefits and Challenges of Immunobridging
   Chairs: Eduardo Franco & Suzanne Garland
   
   
3. Breakout Group 3: DNA Methylation as a triage tool for HPV positives – challenges and lessons learnt
   Chairs: Murat Gultekin & Johannes Berkhof
   

Plenary Feedback

SESSION 6: MEETING CONCLUSION AND CLOSING REMARKS
Chairs: Narendra Kumar Arora & Alex Vorsters 

• Conclusions and Concluding Remarks (, )​